About The Patani Lab


Our Research

Motor neuron disease (MND) is an untreatable and rapidly progressive fatal condition. In order to develop treatments to slow down, stop and ideally repair the damage, we must first understand precisely what is going wrong and where.

Starting with the 'what'; recent studies confirm that problems are occurring with the messages that make protein in cells. This leads to protein misplacement and malfunction.

Until now we have been probing this system with blunt tools but our current array of primary and collaborative laboratory techniques allow us to precisely understand what is going wrong. This is like comparing an old map to a new GPS that can tell you the position of an object in a room of a house on the street you are looking for.

As for the ‘where’, we may instinctively think that the main problem in motor neuron disease lies within the motor nerves. Although this seems logical, we now know from careful studies that the disease is not that simple and that actually, the supportive cells called glia (not nerve cells) may well be the primary culprits.

Resolving these issues will allow rationally engineered and targeted therapies to treat this devastating condition.

The ideal technology for this project is human induced pluripotent stem cells (hiPSCs), which allow the generation of theoretically unlimited numbers of the MND patients very own motor nerves and glia in a petri-dish.

Our Team

The Patani Lab is a group of scientists based at the Institute of Neurology which is part of University College London and we use motor neurons that we grow from patient-derived stem cells to study what happens in motor neuron disease.

How You Can Be Involved

The aim of this website is to keep you updated on the latest discoveries about stem cells and motor neuron disease from the lab.

We would be really interested in your comments. What do you think about our research? What do you think about the website? What would you like to hear more about?

Send us feedback

Our Missions

Learn more about the Lab follow our channel
Watch

Latest From The Lab

The Crick: Patani lab latest news

Seeking a cure for ALS

Colouring in Competition

A huge thank you to KD-UK

The Max Perutz science writing award

Running 100km to raise money for MND research.

Huge congratulations to Claire

Meet The Lab Research Team

Rickie Patani

Lab Supervisor

Yiran Wang

Postdoctoral researcher

Jasmine Harley

PhD student

Helen Devine

PhD Student

Oliver Ziff

PhD student

Camilla Højland Knudsen

PhD student

Ben Clarke

Visiting PhD student

Viren Pandya

PhD student

Doaa Taha

PhD student

Jacob Neeves

PhD student

Marija Petric-Howe

Postdoctoral researcher

Hamish Crerar

Postdoctoral researcher

Martina Halleger

Alumni

Rubika Balendra

Alumni

Claire Hall

Alumni

Philip Smethurst

Alumni

Fredrique Rau

Alumni

Sarah Wiethoff

Alumni

Jamie Mitchell

PhD student

Giulia Tyzack

Postdoctoral researcher


Our Funding Partners