As for the ‘where’, we may instinctively think that the main problem in motor neuron disease lies within the motor nerves. Although this seems logical, we now know from careful studies that the disease is not that simple and that actually, the supportive cells called glia (not nerve cells) may well be the primary culprits.

Resolving these issues will allow rationally engineered and targeted therapies to treat this devastating condition.

The ideal technology for this project is human induced pluripotent stem cells (hiPSCs), which allow the generation of theoretically unlimited numbers of the MND patients very own motor nerves and glia in a petri-dish.

Our Team

The Patani Lab is a group of scientists based at the Institute of Neurology which is part of University College London and we use motor neurons that we grow from patient-derived stem cells to study what happens in motor neuron disease.

How You Can Be Involved

The aim of this website is to keep you updated on the latest discoveries about stem cells and motor neuron disease from the lab.

We would be really interested in your comments. What do you think about our research? What do you think about the website? What would you like to hear more about?

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