Rickie Patani
Position: Lab Supervisor

Project: My core goal is to understand molecular mechanisms of MND so that we can find a cure.


Life in the Lab

I see disease as a crime. In order to accurately investigate a crime scene, detectives meticulously examine each piece of evidence to try to reconstruct the events as far as possible, much like scientists examining a research question. The ideal situation for a detective is to have access to a frame-by-frame recording of the crime scene from the moments before it started, allowing a precise sequence of events to be established. This in turn allows the detective to both understand the cause of the problem and offer a targeted solution to stop similar crimes from occurring in the future.

These same principles hold true in science; remarkably, we can now ‘replay’ initiating disease events within any specific type of cell in the human body to understand how it becomes diseased in a specific patient. Using insights from a Nobel prize-winning discovery made about 10 years ago, we convert skin cells into ‘younger versions’ of any cell type within the human body. By ‘rewinding the clock’ in these cells and subsequently transforming them into different mature cell types, we can establish precisely when and where the problem begins, and which parts of the cell’s machinery are involved… Our lab is utterly committed to harnessing this unparalleled human experimental system to model disease ‘in a dish’ and ultimately discover new treatments for neurological diseases.

Life outside the Lab

I enjoy running, snooker, reading and cooking. I love nature and feeling connected to an evolving and dynamic world.

Related links

Google Scholar | Research Gate | LinkedIn | Twitter | The Crick | UCL

Rickie Patani

Lab Supervisor

Yiran Wang

Postdoctoral researcher

Jasmine Harley

PhD student

Helen Devine

PhD Student

Oliver Ziff

PhD student

Camilla Højland Knudsen

PhD student

Ben Clarke

Visiting PhD student

Viren Pandya

PhD student

Doaa Taha

PhD student

Jacob Neeves

PhD student