Oliver Ziff
Position: PhD student

Project: RNA misprocessing in ALS


Life in the Lab

I am a Neurology registrar and PhD student on the Francis Crick Clinical Fellow programme. I am supervised by Prof Rickie Patani and Prof Nick Luscombe. I am using computational techniques to examine how RNA processing breaks down in ALS by identifying changes in RNA transcripts in both sporadic and familial forms of the disease. The Patani lab have created a stem cell model of human ALS, which we are utilising to understand how changes in RNA processing causes disease. We have uncovered that the earliest detectable change in ALS is failure to accurately remove the non-coding intron sequences (splicing) at the appropriate time points during motor neurone development. However, whether the malfunction of RNA metabolism is a common mechanism across all forms ALS (familial and sporadic) remains to be determined.

Life outside the Lab

I love distance running and Leeds United in equal measure. I am a keen sportsman and was fortunate to travel around the world whilst competing in triathlon.

Related links

Google Scholar | Research Gate | LinkedIn | Twitter | The Crick

Rickie Patani

Lab Supervisor

Yiran Wang

Postdoctoral researcher

Jasmine Harley

PhD student

Helen Devine

PhD Student

Oliver Ziff

PhD student

Camilla Højland Knudsen

PhD student

Ben Clarke

Visiting PhD student

Viren Pandya

PhD student

Doaa Taha

PhD student

Jacob Neeves

PhD student